Pegaspargase

Pegaspargase bulk

Pegylated L-Asparaginase offering extended half-life for effective leukemia treatment

Product characteristics

  • Pegaspargase (CAS Number 130167-69-0) is a PEGylated form of L-Asparaginase, wherein L-Asparaginase is glycol conjugated with mono-methoxy polyethylene glycol (mPEG)
  • Pegaspargase exhibits higher catalytic activity and stability with low hypersensitivity
  • Molecular weight of Pegaspargase is in the range of 450 to 550 kDa with 90 to 100% PEGylation
  • Pegaspargase improves the circulation time in blood and shows resistance to proteolytic reactions

THERAPEUTIC PROPERTIES

  • Pegaspargase is used in the treatment of acute lymphocytic leukaemia (ALL), Non-Hodgkin’s lymphoma and when hypersensitive to another form of L-Asparaginase

Product Features

  • L-Asparaginase manufactured in the in-house WHO-GMP certified facility is used in the Pegaspargase manufacturing
  • mono-methoxy Polyethylene glycol (mPEG) used is sourced from GMP and ISO 9001-2021 certified facility
  • Purity levels ≥95%, confirmed by orthogonal quality control tests
  • Process and product related impurities such as bacterial endotoxins and PEG-derived impurities comply to limits set by competent authorities
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